Central Englewood can be roughly divided into quadrants, with the x-axis being Hampden Avenue and the y-axis being Broadway. The northwest is the oldest section of the city, containing the new CityCenter, downtown, and housing stock dating to the 1910s. This is also where the massive General Iron metal fabrication plant was located, which closed in the 1990s and has now been demolished, awaiting redevelopment and a new proposed light rail station at Bates Avenue. The southwest section is home to a newer housing stock as well as a significant percentage of Englewood’s industrial and production facilities.

The southwest side also features Englewood’s largest park, Belleview Park, and a small reservoir. The southeast section is almost purely residential and is newer than the north and southwest sides. Finally, northeast Englewood is home to one of the largest hospital complexes in the metro area. Swedish Medical Center and Craig Hospital, a top-ten nationally ranked rehabilitation hospital for spinal cord and traumatic brain injury rehabilitation, comprise the hospital district, the backbone of the city economy. The Hampden Hills neighborhood hosts one of the largest conglomeration of apartment complexes in the metro area, and is also the newest developed part of the city as well as the wealthiest.

Englewood also features some large annexed areas, such as the northwest annex that extends to Evans Avenue in Denver, which is chiefly manufacturing and industry. Finally, Englewood extends southeast to the Highline Canal, and southwest past Federal Blvd. approaching the Town of Bow Mar.