Its boundaries are Colfax Avenue to the north, 6th Avenue to the south, Colorado Boulevard to the west, and Holly Street to the east.

The old locations of the University of Colorado Hospital and University of Colorado Denver medical school are located in the Hale Neighborhood along Colorado Boulevard. This site is currently awaiting redevelopment.

The Veterans Affairs Eastern Colorado Health Care System hospital is also located in the Hale neighborhood. The VA hospital is slated to relocate to the Anschutz Medical Campus in Aurora, Colorado after 2013. The future of the current VA hospital building and site is to be determined. Rose Medical Center is located in the neighborhood, and National Jewish Health also owns property on the east side of Colorado Boulevard within the neighborhood. National Jewish recently acquired the old property of Gove Middle School, bordered by Colorado Boulevard, Ash Street, 13th avenue, and 14th avenue.